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Many of magnesiums beneficial effects are related to (a) its role as an antagonist of calcium in the body and (b) its role in regulating inflammation and oxidative stress, [12] which are intimately involved in the development of chronic diseases (e.g., type 2 diabetes, hypertension). Introduction. Magnesium L-threonate is often used for its potential brain benefits and may help manage certain brain disorders, such as depression and age-related memory loss. Find out everything you need to know about diabetes here. TODAY Magnesium regulates the insulin signaling pathway and affects insulin secretion from makes MicroMag the best Magnesium supplement for correcting a magnesium deficiency. Magnesium l-threonate is a relatively new magnesium chelate thats designed to help magnesium enter the brain. Magnesium citrate is best taken when your stomach is empty with a glass of juice or water to help absorption. 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